Meningitis is the most common illness caused by Cryptococcus. Meningitis is an infection of the lining of the spinal cord and brain. It can cause coma and death. Cryptococcus can also infect the skin, lungs, or other parts of the body. The risk of cryptococcal infection is highest when your CD4 counts are below 100. Cryptococcal meningitis is a major HIV-related opportunistic infection, especially in the developing world. A recent study estimated that there are 1 million cases each year. <source http://www.aidsinfonet.org
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